Fig. 3.

A. cinnamomea treatment improved pulmonary respiratory function index (Penh) in a bleomycin-induced pulmonary fibrosis mouse model. Mice were intratracheally administered bleomycin or PBS on day 0, and started orally gavaging A. cinnamomea (A.C.) or PBS on day 3, orally once a day, five times a week for 18 days. Whole-body plethysmograph (WBP) was employed and Penh was used as a noninvasive index of airway dysfunction on days 3 (A) and 21 (B) after BLM administration. Penh values were determined relative to those of the PBS treatment controls. Each dot represents an individual mouse with the mean shown for n ≥ 6 per group. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.