Fig. 5.

Effects of A. cinnamomea extract on histopathologic changes in bleomycin-induced pulmonary fibrosis mice. Mice were administered bleomycin (BLM) or PBS on day 0, The treatment groups received orally with A. cinnamomea (A.C.), or PBS on day 3, orally once a day, five times a week for 18 days. Lung tissues were collected 21 days after bleomycin administration for sectioning and H&E staining. Mice were sacrificed on day 21 and lung samples were collected for further analysis. (A) Representative photographs of H&E and Masson's trichrome staining of lung tissue sections in the indicated groups. Scale bar: 100 μm. (B) Ashcroft fibrosis scores were used to evaluate the degree of lung fibrosis. Data are represented as the mean ± SEM (n ≥ 6 per group). ^#p < 0.05 compared with vehicle-treated control group. ∗p < 0.05 compared with BLM group.