Fig. 2.

Efficacy of biologics on reduced sense of smell assessed using UPSIT (A–C) and on HRQoL assessed using SNOT-22 (D–F) in phase III clinical trials. Data from ^aBachert et al. [43]; ^bGevaert et al. [45]; ^cHan et al. [46]. HRQoL health-related quality of life, LS least-squares, q2w every 2 weeks, q4w every 4 weeks, SNOT-22 22-item Sino-Nasal Outcome Test, UPSIT University of Pennsylvania Smell Identification Test