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. 2024 Nov 9;15(11):810. doi: 10.1038/s41419-024-07204-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A RB and p53 wild type HCT116 and HT1080 cells were treated for the indicated number of days with 0.2 μM AZD2811, then harvested and lysates immunoblotted for the indicated proteins. DREAM repressed cell cycle regulators (defined in [23]) are highlighted in red. This is representative of two independent experiments. B The levels of the DREAM repressed cell cycle regulators in (A) were quantified, expressed as percentage of control and combined. C The indicated HCT116 genotypes were treated for the indicated times with 0.2 μM AZD2811, harvested and lysates immunoblotted for the indicated proteins. The data are representative of replicate immunoblots. D The combined changes in cell cycle regulators from (C). E HCT116 wild type, RB deleted and RB+p53 deleted, MCF7 wild type and RB deleted lines were treated for the indicated times with 0.2 μM AZD2811 and immunoblotted for the indicated proteins. α-Tubulin was used as a loading control.