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. 2024 Oct 26;10(21):e39890. doi: 10.1016/j.heliyon.2024.e39890

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© 2024 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 1 — Effects of lactucin on cell viability and intracellular lipid accumulation in HepG2 cells. (A) HepG2 cells were treated with 0 (1), 5 (2), 10 (3), or 20 (4) μmol/L lactucin for 48 h, and cell morphology was observed. (B) CCK-8 assay was used to measure the cell survival rate and IC50 (C). (D) The TG enzyme method was used to determine the changes in triglyceride content in HepG2 cells after FFA intervention and treatment with different concentrations of lactucin for 48 h. (E) RT‒PCR was used to detect the mRNA levels of SREBP-1 in cells. (F–G) Effect on intracellular lipid accumulation in HepG2 cells as observed by oil red O staining. (5) Control, (6) FFA (0.4 mM, OA:PA = 2:1), (7) FFA+5 μmol/L lactucin, (8) FFA+10 μmol/L lactucin, (9) FFA+20 μmol/L lactucin.