Fig. 3.

Metabolic assessments. (a, b, c, d) Area under the glucose time curve (AUC) of intraperitoneal glucose tolerance test (IP-GTT) for the 2- and 8-week experiments; (e, f, g, h) IP-GTT curves at baseline, preoperative, 2 weeks postoperative and 8 weeks postoperative of the 8-week study. (a–b) and (e–f) show no differences between the groups at the baseline and the preoperative timepoint. (c) Glucose tolerance improved after SG 2 weeks after surgery, which is depicted as a decrease in IP-GTT AUC compared to sham operated animals. (d) Regarding the long-term experiment, 8 weeks after surgery the IP-GTT AUC is still decreased after SG compared to control and Pf, but without being statistically significant. (i) cholesterol levels before termination of the experiment (2 and 8 weeks after surgery). Cholesterol levels are decreased in the SG groups 2- and 8-weeks following surgery. (j) Triglyceride levels do not differ between groups at both time points. ∗p < 0:05, ∗∗p < 0:01 and ∗∗∗p < 0:001.