Table 4.
Initial Response to Treatment and Related Factors
| Responder n:63, % | Non-Responder n:36, % | p | t test | |
|---|---|---|---|---|
| Male sex | 37 (58.7) | 27 (75.0) | 0.103 | |
| PSIa class | t (97)=−1.94, p=0.045 | |||
| I | 2 (5.0) | 0 | - | |
| II | 12 (32.4) | 4 (11.1) | 0.302 | |
| III | 11 (29.7) | 4 (11.1) | 0.396 | |
| IV | 23 (62.1) | 15 (41.6) | 0.611 | |
| V | 15 (40.5) | 13 (36.1) | 0.191 | |
| CURB-65b score | t (97)=−1.15, p=0.256 | |||
| 0 | 13 (20.6) | 6 (16.6) | 0.629 | |
| 1 | 16 (25.3) | 8 (22.2) | 0.722 | |
| 2 | 23 (36.5) | 12 (33.3) | 0.750 | |
| 3 | 8 (12.6) | 6 (16.6) | 0.585 | |
| 4 | 3 (4.0) | 4 (11.1) | 0.235 | |
| 5 | - | - | ||
| CCIc | t (97)=−1.30, p=0.232 | |||
| ≥ 6 points | 17d (28.3) | 15 (41.6) | 0.179 | |
| Age in years ≥ 65 | 29 (46.0) | 20 (55.5) | 0.361 | t (97)=−0.16, p=0.871 |
| Respiratory Rate | 0.041 | t (96)=−2.04, p=0.043 | ||
| Empirical Antibiotherapy | ||||
| B-lactam | 27 (42.8) | 11 (30.5) | 0.256 | |
| B-lactam+Macrolide | 15 (23.8) | 11 (30.5) | 0.415 | |
| B-lactam+FQe | 15 (23.8) | 10 (27.7) | 0.608 | |
| FQ | 4 (6.0) | 2 (5.0) | 0.896 | |
| Time to initial antibiotic administration (first hour) | 18 (27.6) | 15 (41.6) | 0.185 | |
| CRPf (mg/L) | 0.991 | t (97)=0.12, p=0.991 | ||
| Procalcitonin (ng/mL) | 0.115 | t (81)=−0.99, p=0.921 | ||
| Leucocyte (cells/mm3) | 0.534 | t (97)=−0.59, p=0.555 | ||
| LDHg | 0.008 | t (89)=−2.82, p=0.006 |
Notes: aPSI; Pneumonia severity index, bCURB-65; Confusion, urea, respiratory rate, blood pressure, cCCI; Charlson’s Comorbidity Index, d3 missing data, eFQ; Fluoroquinolone, fCRP; C-reactive peptide, gLDH; Lactate dehydrogenase.