Fig. 7.
The pharmacological blockage of purinergic A2B receptor restores the phagocytic index of macrophages from S. mansoni-infected mice. Macrophages from both groups were incubated with the selective A2A receptor agonist CGS21680 (1 μM, A) or with the selective A2B receptor antagonist MRS1706 (1 μM, B) for 30 min before exposition to L. amazonensis. Data expressed as mean and SEM. n = 5–8 individual animals for each group, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, one way ANOVA followed by Tukey's multiple comparisons test (A, B) or Student's t-test (B, S.m.-infected + MRS1706). S.m. = S. mansoni