Table 5. Comparison between prior antibiotic therapy during the first week of illness and no prior antibiotics with infectious complications.

ICU: intensive care unit; MDR: multi-drug resistance *P-values <0.05 are considered significant.

Parameters	Patients with prior antibiotic exposure in the first week (N=38)	Patients with no prior antibiotic exposure in the first week (N=92)	p-value
Infected necrosis (pancreatic(peri) infection), n(%)	15 (39.47%)	24 (26.08%)	0.128
Extrapancreatic infections, n(%)	8 (21.05%)	12 (13.04%)	0.164
Combined infection, n(%)	19 (50%)	17 (18.47%)	0.001*
MDR organisms, n(%)	24 (63.15%)	22 (23.91%)	<0.001*
Fungal infection, n(%)	4 (10.52%)	2 (2.1%)	0.012*
Need for intervention, n (%)	26(68.42%)	62(67.3%)	0.254
Need for surgery, n (%)	10(26.3%)	8(8.6%)	0.066*
Need for ICU, n (%)	25(65.78%)	30(32.60%)	0.002*
Mortality, n (%)	15(39.47%)	13(14.13%)	0.018*