Fig. 1.

Pyruvate kinase encoded by PKM relates to renal urate reabsorption In the glycolytic system in the tissues such as muscle (A), pyruvate kinase ultimately metabolizes phosphoenolpyruvate to pyruvate, which results in an increase in lactate. In the kidney (B), lactate is known to enhance renal urate reabsorption via urate transporter 1 (URAT1/SLC22A12), which leads to an increase in serum urate levels and gout susceptibility