Figure 1.

CKD micro-simulation flowchart. ^aNone, partial, or unlimited based on proportion of patients within a population. ^beGFR was updated based on regression equations (Supplementary Table S2). UACR was updated in each cycle a patient transitioned between age strata (i.e., increments of 10 years from age 25 onward) based on country-specific albuminuria distributions. Note: Patients could experience CV (stroke, MI, AKI, HF hospitalization) that were not modeled as disease states. Medical history includes history of stroke or MI. Comorbidities include HF, hypertension, and diabetes. AKI, acute kidney disease; CKD, chronic kidney disease; CV, cardiovascular; dx, diagnosis; eGFR, estimated glomerular filtration rate; HF, heart failure; MI, myocardial infarction; pts, patients; RRT, renal replacement therapy; UACR, albumin-creatinine ratio; t, cycle; T, time horizon.