Table 2.
Demographic, clinical, and gene mutation data in the training set, categorized by the penalized MCM as cured or susceptible with low risk or high risk
| Characteristica | Cured (n = 129) | Low risk (n = 79) | High risk (n = 89) | p Value |
|---|---|---|---|---|
| Age, years | 44 (18–59) | 43 (19–59) | 44 (17–59) | 0.495 |
| Sex | 0.785 | |||
| Female | 56 (43.4) | 38 (48.1) | 39 (43.8) | |
| Male | 73 (56.6) | 41 (51.9) | 50 (56.2) | |
| Hemoglobin, g/dL | 9.2 (3.1–25.1) | 9.1 (4.9–14.0) | 9.1 (2.3–14.2) | 0.680 |
| Platelet count, ×109/L | 50 (8–369) | 47 (7–433) | 43 (7–271) | 0.106 |
| White blood cell count, ×109/L | 23.5 (1.8–298.4) | 29.9 (0.6–158.5) | 27.8 (0.4–303.6) | 0.419 |
| Bone marrow blasts, % | 61.5 (2–97) | 65.0 (18–95) | 63.0 (23–95) | 0.068 |
| Blood blasts, % | 49 (0–97) | 57 (0–97) | 56 (1–97) | 0.198 |
| Cytogenetic groups, % | ||||
| Core-binding factor AML | 52 (40.3) | 24 (30.4) | 36 (40.4) | 0.292 |
| inv(16)(p13.1q22) | 30 (23.3) | 20 (25.3) | 23 (25.8) | 0.898 |
| t(8;21)(q22;q22) | 22 (17.1) | 4 (5.1) | 13 (14.6) | 0.029 |
| Sole +8 | 0 | 2 (2.5) | 1 (1.1) | 0.108 |
| DNMT3A | 0.762 | |||
| Mutated | 30 (23.3) | 15 (19.0) | 18 (20.2) | |
| Wild-type | 99 (76.7) | 64 (81.0) | 71 (79.8) | |
| NRAS | 0.232 | |||
| Mutated | 26 (20.2) | 13 (16.5) | 24 (27.0) | |
| Wild-type | 103 (79.8) | 66 (83.5) | 65 (73.0) | |
| SF3B1 | 0.279 | |||
| Mutated | 2 (1.6) | 0 | 3 (3.4) | |
| Wild-type | 127 (98.4) | 79 (100.0) | 86 (96.6) | |
| IDH1 | 0.318 | |||
| Mutated | 5 (3.9) | 7 (8.9) | 6 (6.7) | |
| Wild-type | 124 (96.1) | 72 (91.1) | 83 (93.3) | |
| CEBPAbzip | 0.612 | |||
| Mutated | 25 (19.4) | 13 (16.5) | 20 (22.5) | |
| Wild-type | 104 (80.6) | 66 (83.5) | 69 (77.5) | |
| GATA2 | 0.488 | |||
| Mutated | 10 (7.8) | 4 (5.1) | 9 (10.1) | |
| Wild-type | 119 (92.2) | 75 (94.9) | 80 (89.9) | |
| TET2 | 0.138 | |||
| Mutated | 9 (7.0) | 10 (12.7) | 4 (4.5) | |
| Wild-type | 120 (93.0) | 69 (87.3) | 85 (95.5) | |
| NPM1 | 0.014 | |||
| Mutated | 53 (41.1) | 46 (58.2) | 33 (37.1) | |
| Wild-type | 76 (58.9) | 33 (41.8) | 56 (62.9) | |
| WT1 | 0.182 | |||
| Mutated | 4 (3.1) | 7 (8.9) | 6 (6.7) | |
| Wild-type | 125 (96.9) | 72 (91.1) | 83 (93.3) | |
| PTPN11 | 0.158 | |||
| Mutated | 10 (7.8) | 13 (16.5) | 9 (10.1) | |
| Wild-type | 119 (92.2) | 66 (83.5) | 80 (89.9) | |
| FLT3 TKD | 0.076 | |||
| Present | 21 (16.4) | 15 (19.2) | 7 (7.9) | |
| Absent | 107 (83.6) | 63 (80.8) | 82 (92.1) | |
| FLT3 ITD | 1.00 | |||
| Present | 4 (3.1) | 3 (3.8) | 3 (3.4) | |
| Absent | 124 (96.9) | 75 (96.2) | 85 (96.6) | |
| IDH2 | 0.342 | |||
| Mutated | 4 (3.1) | 6 (7.6) | 4 (4.5) | |
| Wild-type | 125 (96.9) | 73 (92.4) | 85 (95.5) | |
| MLL-PTD | 0.274 | |||
| Present | 3 (10.0) | 0 | 0 | |
| Absent | 27 (90.0) | 23 (100.0) | 10 (100.0) | |
| TP53 | 0.566 | |||
| Mutated | 0 | 0 | 1 (1.1) | |
| Wild-type | 129 (100.0) | 79 (100.0) | 88 (98.9) | |
| SRSF2 | 0.180 | |||
| Mutated | 0 (0.0) | 1 (1.3) | 2 (2.3) | |
| Wild-type | 128 (100.0) | 78 (98.7) | 86 (97.7) | |
| ASXL1 | 0.790 | |||
| Mutated | 2 (1.6) | 0 | 1 (1.1) | |
| Wild-type | 127 (98.4) | 79 (100.0) | 88 (98.9) | |
| RUNX1 | 0.319 | |||
| Mutated | 0 | 1 (1.3) | 1 (1.1) | |
| Wild-type | 129 (100.0) | 78 (98.7) | 88 (98.9) | |
| BCOR | 0.469 | |||
| Mutated | 1 (0.8) | 0 | 2 (2.2) | |
| Wild-type | 128 (99.2) | 79 (100.0) | 87 (97.8) |
a
Continuous variables were summarized by reporting the median (range), while categorical variables were summarized by reporting frequency (percentage).