Table 3.
Demographic, clinical, and gene mutation data in the test set, categorized by the MCM as cured or susceptible with low or high risk of relapse or death
| Characteristica | Cured (n = 40) | Low risk (n = 19) | High risk (n = 16) | p Value |
|---|---|---|---|---|
| Age, years | 40.5 (18–59) | 43 (20–57) | 47.5 (22–58) | 0.319 |
| Sex | 0.069 | |||
| Female | 17 (42.5) | 14 (73.7) | 7 (43.8) | |
| Male | 23 (57.5) | 5 (26.3) | 9 (56.2) | |
| Hemoglobin, g/dL | 8.7 (3.5–13.4) | 9.2 (6.0–12.4) | 8.95 (4.2–13.3) | 0.944 |
| Platelet count, ×109/L | 35 (4–273) | 42 (11–268) | 47 (14–301) | 0.547 |
| White blood cell count, ×109/L | 20.35 (3.0–262.5) | 26 (1.1–206.0) | 43.48 (1.33–316.0) | 0.758 |
| Bone marrow blasts, % | 70 (20–97) | 70 (30–100) | 86.5 (30–95) | 0.549 |
| DNMT3A | 0.018 | |||
| Mutated | 3 (7.5) | 7 (36.8) | 3 (18.8) | |
| Wild-type | 37 (92.5) | 12 (63.2) | 13 (81.2) | |
| NRAS | 0.630 | |||
| Mutated | 14 (35.0) | 4 (21.1) | 5 (31.2) | |
| Wild-type | 26 (65.0) | 15 (78.9) | 11 (68.8) | |
| SF3B1 | N/A | |||
| Mutated | 0 | 0 | 0 | |
| Wild-type | 40 (100.0) | 19 (100.0) | 16 (100.0) | |
| IDH1 | 0.011 | |||
| Mutated | 0 | 3 (15.8) | 3 (18.8) | |
| Wild-type | 40 (100.0) | 16 (84.2) | 13 (81.2) | |
| CEBPAbzip | 0.117 | |||
| Mutated | 6 (15.0) | 2 (10.5) | 6 (37.5) | |
| Wild-type | 34 (85.0) | 17 (89.5) | 10 (62.5) | |
| GATA2 | 1.00 | |||
| Mutated | 2 (5.0) | 1 (5.3) | 0 | |
| Wild-type | 38 (95.0) | 18 (94.7) | 16 (100.0) | |
| TET2 | 0.414 | |||
| Mutated | 3 (7.5) | 2 (10.5) | 3 (18.8) | |
| Wild-type | 37 (92.5) | 17 (89.5) | 13 (81.2) | |
| NPM1 | 0.184 | |||
| Mutated | 11 (27.5) | 10 (52.6) | 5 (31.2) | |
| Wild-type | 29 (72.5) | 9 (47.4) | 11 (68.8) | |
| WT1 | 1.00 | |||
| Mutated | 7 (17.5) | 3 (15.8) | 2 (12.5) | |
| Wild-type | 33 (82.5) | 16 (84.2) | 14 (87.5) | |
| PTPN11 | 0.334 | |||
| Mutated | 4 (10.0) | 3 (15.8) | 0 | |
| Wild-type | 36 (90.0) | 16 (84.2) | 16 (100.0) | |
| FLT3 TKD | 0.329 | |||
| Present | 7 (17.5) | 5 (26.3) | 1 (6.2) | |
| Absent | 33 (82.5) | 14 (73.7) | 15 (93.8) | |
| FLT3 ITD | 0.862 | |||
| Present | 3 (7.5) | 2 (10.5) | 1 (6.2) | |
| Absent | 37 (92.5) | 17 (89.5) | 15 (93.8) | |
| IDH2 | 0.826 | |||
| Mutated | 2 (5.0) | 2 (10.5) | 1 (6.2) | |
| Wild-type | 38 (95.0) | 17 (89.5) | 15 (93.8) | |
| MLL-PTD | N/A | |||
| Present | 0 | 0 | 0 | |
| Absent | 39 (100.0) | 19 (100.0) | 15 (100.0) | |
| TP53 | N/A | |||
| Mutated | 0 | 0 | 0 | |
| Wild-type | 40 (100.0) | 19 (100.0) | 16 (100.0) | |
| SRSF2 | 0.467 | |||
| Mutated | 0 | 1 (5.3) | 0 | |
| Wild-type | 40 (100.0) | 18 (94.7) | 16 (100.0) | |
| ASXL1 | 1.000 | |||
| Mutated | 2 (5.0) | 0 | 0 | |
| Wild-type | 38 (95.0) | 19 (100.0) | 16 (100.0) | |
| RUNX1 | N/A | |||
| Mutated | 0 | 0 | 0 | |
| Wild-type | 40 (100.0) | 19 (100.0) | 16 (100.0) | |
| BCOR | 0.467 | |||
| Mutated | 0 | 1 (5.3) | 0 | |
| Wild-type | 40 (100.0) | 18 (94.7) | 16 (100.0) |
a
Continuous variables were summarized by reporting the median (range), while categorical variables were summarized by reporting frequency (percentage).