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. Author manuscript; available in PMC: 2024 Nov 11.
Published in final edited form as: Ophthalmology. 2013 Jan 16;120(4):844–851. doi: 10.1016/j.ophtha.2012.10.036

Table 1.

Five-Year Rate of Developing Advanced AMD in AREDS Participants by Drusen Size and Degree of Pigmentary Abnormalities

Drusen Size Pigmentary Abnormalities None Pigmentary Abnormalities One Eye Pigmentary Abnormalities Both Eyes
None or small drusen 0.4% (4/1017) 0% (0/64) 12.5% (1/8)
Intermediate drusen one eye no large drusen 0.5% (2/449) 5.0% (5/101) 12.9% (4/31)
Intermediate drusen both eyes no large drusen 2.1% (4/187) 12% (6/50) 20% (7/35)
Large drusen one eye 3.9% (11/283) 10.1% (17/168) 25.6% (30/117)
Large drusen both eyes 13% (27/208) 27.3% (48/176) 47.3% (150/317)

AMD = age-related macular degeneration; AREDS = Age-Related Eye Disease Study.