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. Author manuscript; available in PMC: 2024 Nov 11.
Published in final edited form as: JAMA Ophthalmol. 2014 Mar;132(3):272–277. doi: 10.1001/jamaophthalmol.2013.6636

Table.

Comparison of Participants and Nonparticipants in AREDS Follow-up Studya

No. of Surviving AREDS Participants AREDS Participants Active in the Follow-up Study, % P Valueb
All 4203 84.4
AMD category
 1 1031 88.5 <.001
 2 960 85.8
 3 1435 83.8
 4 777 78.6
AREDS treatment assignment
 Placebo 1312 83.8 .61
 Antioxidants 1301 85.3
 Zinc 806 83.5
 Antioxidants plus zinc 784 84.9
Age, y
<65 957 90.4 <.001
 65–69 1432 87.6
 ≥70 1814 78.8
Sex
 Female 2412 84.2 .69
 Male 1791 84.7
Educational levelc
 High school or less 1460 80.7 <.001
 Some college 1285 83.7
 College graduate 1455 88.8
Race
 Nonwhite 179 77.1 .006
 White 4024 84.8
Smoking status
 Never 1931 87.1 <.001
 Former 1974 83.2
 Current 298 75.5
BMId
 <24.9 1369 85.1 .08
 25.0–29.9 1761 85.2
 ≥30.0 1071 82.3
Hypertension
 Normal 2611 86.6
 Controlled 993 82.0 <.001
 Uncontrolled and treated 280 76.8
 Uncontrolled and untreated 319 81.5
Angina
 No 3802 84.8 .07
 Yes 401 81.3
Diabetes mellitus
 No 3886 84.8 .007
 Yes 317 81.3

Abbreviations: AMD, age-related macular degeneration; AREDS, Age-Related Eye Disease Study; BMI, body mass index (calculated as weight in kilograms divided by height in meters squared).

a

Of the original 4757 AREDS participants enrolled in the controlled clinical trial (1992–2001), 554 (11.6%) died at the end of the clinical trial, with 4203 surviving at the beginning of the follow-up study (October 1, 2001).

b

Calculated by the χ2 test.

c

Three partipants were missing data.

d

Two participants were missing data.