Table 1.
Features of gastric hyperplastic polyps in different groups and univariate logistic regression analysis of risk factors for neoplastic transformation
|
|
GHPs without IN (n = 3874)
|
GHPs with IN (n = 136) |
χ
2 test
|
Univariate analysis
|
||
|
χ
2 value
|
P value
|
P value
|
OR (95%CI)
|
|||
| Age (mean ± SD), years | 57.86 ± 0.22 | 64.76 ± 1.04 | 37.178 | < 0.001 | < 0.001 | 1.761 (1.459-2.126) |
| ≤ 45 years, n (%) | 699 (18) | 9 (6) | ||||
| 45-65 years, n (%) | 1988 (51) | 54 (40) | ||||
| > 65 years, n (%) | 1187 (31) | 73 (54) | ||||
| Sex, n (%) | 9.057 | 0.011 | 0.003 | 1.672 (1.188-2.356) | ||
| Male | 1423 (37) | 67 (49) | ||||
| Female | 2451 (63) | 69 (51) | ||||
| H. pylori infection, n (%) | 782 (20) | 22 (16) | 1.865 | 0.172 | 0.174 | 0.721 (0.450-1.155) |
| Multiple polyps, n (%) | 1122 (29.4) | 62 (46) | 23.162 | < 0.001 | < 0.001 | 2.275 (1.614-3.207) |
| Polyp size (mean ± SD), cm | 0.66 ± 0.01 | 203.055 | < 0.001 | < 0.001 | 3.634 (2.948-4.478) | |
| ≤ 1 cm | 3406 (88) | 66 (48) | ||||
| 1 cm-2 cm | 374 (10) | 53 (39) | ||||
| > 2 cm | 94 (2) | 17 (13) | ||||
| Endoscopic color, n (%) | 18.626 | < 0.001 | 0.03 | 0.671 (0.472-0.972) | ||
| Normal | 2113 (55) | 53 (40) | ||||
| Red | 1488 (40) | 82 (60) | ||||
| White | 275 (5) | 1 (0) | ||||
| Mucosal erosion, n (%) | 289 (8) | 30 (22) | 38.701 | < 0.001 | < 0.001 | 3.538 (2.318-5.402) |
| Polyp lobulation, n (%) | 185 (5) | 25 (18) | 49.109 | < 0.001 | < 0.001 | 4.491 (2.840-7.102) |
| Mucosal roughness, n (%) | 864 (22) | 69 (51) | 59.494 | < 0.001 | < 0.001 | 3.588 (2.542-5.064) |
| Endoscopic classification, n (%) | 169.676 | < 0.001 | < 0.001 | 2.604 (2.210-3.067) | ||
| I | 2480 (64) | 35 (26) | ||||
| II | 1007 (26) | 42 (31) | ||||
| III | 233 (6) | 27 (20) | ||||
| IV | 155 (4) | 32 (23) | ||||
| Location, n (%) | 23.926 | < 0.001 | < 0.001 | 1.750 (1.384-2.212) | ||
| Upper third | 1457 (38) | 31 (23) | ||||
| Middle third | 1715 (44) | 60 (44) | ||||
| Lower third | 702 (18) | 45 (33) | ||||
| Background gastric mucosa, n (%) | 81.877 | < 0.001 | < 0.001 | 1.699 (1.472-1.960) | ||
| Autoimmune gastritis | 364 (9.4) | 29 (21) | ||||
| Chronic superficial gastritis | 2466 (64) | 42 (31) | ||||
| Chronic atrophic gastritis | 712 (18) | 31 (23) | ||||
| Gastritis with IN | 332 (9) | 34 (25) | ||||
OR: Odds ratio; CI: Confidence interval; GHPs: Gastric hyperplastic polyps; IN: Intraepithelial neoplasia; H. pylori: Helicobacter pylori.