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. 2024 Nov 15;16(11):4468–4476. doi: 10.4251/wjgo.v16.i11.4468

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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Protein expressions in groups. A: Protein expressions of RAS, extracellular-signal-regulated kinase (ERK) and Perk in groups; B: Comparison of the phosphorylated-ERK/ERK and RAS protein expressions in groups; C: Comparison of matrix metalloproteinase 2 (MMP2) and c-myc protein expressions in groups; D: Comparison of MMP2 and c-myc protein expressions in groups. ISAP: Invigorating-spleen and anticancer prescription; ERK: Extracellular-signal-regulated kinase; p-ERK: Phosphorylated extracellular-signal-regulated kinase; MMP2: Matrix metalloproteinase 2.