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. 2024 Nov 7;30(41):4417–4438. doi: 10.3748/wjg.v30.i41.4417

Figure 2.

Figure 2

Illustration of the main methods to measure trypsinogen activation in experimental pancreatitis. A and B: Time-course of changes in the levels of (A) trypsin activity and (B) trypsinogen activation peptide (TAP) measured in pancreas homogenates from rats subjected to i.v. infusion of 5 μg/kg cerulein (adapted from Hofbauer et al[21]), *P < 0.05 versus saline; C: Electron microscopic immunolocalization of TAP in pancreas was measured in (a) untreated rats and (b) 60 minutes after cerulein (5 μg/kg) infusion. Note intense punctate TAP immunoreactivity in small vesicles (arrowheads) and large vacuoles (arrows), which was absent in control[28]. C: Citation: Otani T, Chepilko SM, Grendell JH, Gorelick FS. Codistribution of TAP and the granule membrane protein GRAMP-92 in rat caerulein-induced pancreatitis. Am J Physiol 1998; 275: G999-G1009. Copyright© The American Physiological Society 1998. Published by American Physiological Society. Authors of American Physiological Society articles may reuse their content in reused new works (https://journals.physiology.org/publication-process#copyright).