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. 2024 Nov 11;14(48):35754–35768. doi: 10.1039/d4ra06240j

Summary of LCST-responsive polysaccharides used in biomedical applications.

Polysaccharides Structures Characteristics LCST range (°C) Biomedical applications References
Chitosan graphic file with name d4ra06240j-u6.jpg • Salt- induced phase transition 37 In situ gel-based drug delivery (ocular, wound dressing) 110–112 and 114–116
• Antibacterial property
• Muco-adhesiveness
Xyloglucan graphic file with name d4ra06240j-u7.jpg • Degalactosylation-induced phase transition 37 In situ gel-based drug delivery (nasal, stem cell) 97–99, 121–125, 127, 135, 136 and 138
• Promoting stem cell survival In situ gel-based cellular scaffolds (osteogenic cell)
• Pseudo-plastic flow behavior
• Thermo-sensitivity
Methylcellulose graphic file with name d4ra06240j-u8.jpg • Hydrophobic interaction-based gelation • Topical drug delivery 102, 144, 147, 153, 156 and 163
• Flexible shape and geometry • Bone tissue regeneration
• 3D cellular scaffolds