Table 2.

Association of Risk Factors With Stroke by Stroke Severity

Risk factor	Multinomial logistic regression All stroke			Conditional logistic regression All stroke
	Outcome	Odds ratio (95% CI)a	p Value for heterogeneity	p Value case-case
Hypertension	Severe stroke	3.21 (2.97–3.47)	0.03	<0.001
	Non-severe stroke	2.87 (2.69–3.05)
Atrial fibrillation	Severe stroke	4.70 (4.05–5.45)	0.009	<0.001
	Non-severe stroke	3.61 (3.16–4.13)
Smoking: current smoker	Severe stroke	1.87 (1.72–2.03)	0.02	<0.001
	Non-severe stroke	1.65 (1.54–1.77)
High WHR	Severe stroke	1.11 (1.02–1.20)	<0.001	<0.001
	Non-severe stroke	1.37 (1.28–1.47)
Physical activity (mainly inactive)	Severe stroke	2.05 (1.81–2.32)	<0.001	0.81
	Non-severe stroke	1.47 (1.34–1.60)
Alcohol use (current)	Severe stroke	0.99 (0.90–1.09)	<0.001	0.06
	Non-severe stroke	1.30 (1.21–1.40)
Diabetes mellitus	Severe stroke	1.29 (1.19–1.39)	0.06	0.21
	Non-severe stroke	1.17 (1.10–1.26)
Global stress: several periods/permanent	Severe stroke	1.62 (1.48–1.78)	0.24	0.22
	Non-severe stroke	1.51 (1.40–1.63)
AHEI tertile: tertile 1	Severe stroke	1.28 (1.19–1.38)	0.25	0.86
	Non-severe stroke	1.21 (1.14–1.29)
ApoB >1b	Severe stroke	0.97 (0.90–1.05)	0.006	0.11
	Non-severe stroke	1.11 (1.05–1.18)
ApoA1b: tertile 1	Severe stroke	2.36 (2.17–2.56)	<0.01	0.25
	Non-severe stroke	1.52 (1.42–1.62)

Abbreviations: AHEI = Alternative Healthy Eating Index; WHR = waist-to-hip ratio.

Reference levels: smoking, never/former smoker; physical activity, mainly active; global stress, none or some periods; AHEI, tertile 2/3; ApoA1, tertile 2/3.

^aAdjusted for age, sex, and country and mutually adjusted for risk factors.

^bOwing to missing data, not included in the multivariable model.