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. 2024 Oct 24;16(44):59934–59948. doi: 10.1021/acsami.4c13353

Figure 5.

Figure 5

Effect of chemical modification on specific binding to the ctMPER epitope reconstituted in membranes. A) Binding to POPC:PEG–PE (95:5 mol ratio) vesicles was measured in the absence (left panel) or presence of ctMPER-TMD or ctMPER-TMD(Ala) peptides reconstituted in membranes (center and right panels, respectively). The peptides were included at a 1:250 peptide-to-lipid ratio (mol:mol). B) Binding to PML vesicles including 3 mol % PEG–PE to avoid off-target spontaneous partitioning into membranes (see Figure 4). C) Binding to VL vesicles including 2 or 3 mol % PEG–PE. (****p < 0.0001, ***p < 0.0002, **p < 0.02, *p < 0.03).