Table 1. Atypical diabetes mellitus cases identified with strategy 1 (questionnaire applied to EMR).
| Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | Case 6 | |
| Age (years)* | 9.1 | 9.5 | 8.8 | 10.8 | 15.7 | 12.5 |
| Sex | Male | Female | Female | Female | Female | Female |
| Race/ethnicity | Hispanic | Hispanic | NHW | Hispanic | Hispanic | NHW |
| BMI (%-ile)* | 99.14 | 99.48 | – | 66.28 | 81.07 | 5.72 |
| Diagnosis on EMR | T2D | T2D | T1D | T1D | T2D | T1D |
| Diabetes in parents | Yes | Yes | Yes | Yes | Yes | Yes |
| Acanthosis nigricans | Yes - minimal | Yes | No | No | No | No |
| C-peptide* (ng/mL) | – | 3.66 | – | 1.44 | 1.04 | 0.46 |
| Islet antibodies (GAD65, ICA512 and IAA) | Negative | Negative | Negative | Negative | Negative | Negative |
| ZnT8 antibody | Negative | – | Negative | Negative | Negative | Negative |
| Lipid profile*(mg/dL) | TG 114LDL 135HDL 52TChol 209 | TG 277LDL 79HDL 31TChol 166Non-HDL 135 | – | – | TG 150LDL 90HDL 43TChol 150Non-HDL 107 | TG 102LDL 84HDL 73TChol 177Non-HDL 104 |
| HbA1C (%)* | 5.9 | 9.6 | Not available | 11.7 | 12.9 | >14 |
| Recent HbA1C (%) | 10.8 | >14 | 8.7 | 8.5 | >14 | 8.2 |
| Treatment* | Metformin | Insulin | Insulin | Insulin and metformin | Insulin | Insulin |
| MODY genetic panel | – | – | Negative | VUS on PDX1[heterozygous variant,c.820G>T (p.Val274Phe)] | Negative | Negative |
*
At diagnosis.
BMIbody mass indexEMR, electronic medical record; HDL, high-density lipoprotein; %-ile, percentile; LDL, low-density lipoprotein; MODYmaturity-onset diabetes of the young NHW, non-Hispanic white; Non-HDL, non-HDL cholesterolTChol, total cholesterol; T1D, type 1 diabetes; T2D, type 2 diabetes; TG, triglycerides