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CF10, but not 5-FU, is enhanced by Wee1i and ATRi in four PDAC cell lines. (a, b) the Wee1i (green) and the ATRi (blue) showed enhanced cytotoxicity in all tested cell lines when administered concurrently to CF10 (black, single agent orange). (c, d) Conversely, enhanced effect is not seen in three out of four cell lines, and only modestly in the CFPAC1 cell line, when the Wee1i (green) and ATRi (blue) were administered either concurrently (black) to 5-FU (single agent, magenta).
