Table 3.
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entry | R1 | R2 | base | product | yield, % |
| |||||
1a | p-MeC6H4 | Ph | BuLi | 5a | 13 |
2a,b | p-MeC6H4 | Ph | BuLi | 5a | 24 |
3 | p-MeC6H4 | Ph | BuLi | 5a | 82 |
4 | p-MeC6H4 | Ph | t-BuOK | 5a | 27 |
5 | p-MeC6H4 | Ph | t-BuOLi | 5a | 66 |
6 | p-MeC6H4 | Bu | BuLi | 5b | 45 |
7 | p-MeC6H4 | t-Bu | BuLi | 5c | 56 |
8 | p-MeC6H4 | Me3Si | BuLi | 5d | 52 |
9 | Et | Ph | BuLi | 5e | 70 |
aDry THF was used as solvent; b2 equiv of H2O were added.