KEY RESOURCES TABLE
| REAGENT or RESOURCE | SOURCE | IDENTIFIER |
|---|---|---|
| Antibodies | ||
| Rabbit polyclonal anti-Iba-1 | Wako | Cat#019–19741; RRID: AB_839504 |
| Rabbit polyclonal anti-IL-18 | Abcam | Cat# ab191152; RRID: AB_2737346 |
| Mouse monoclonal anti-IL-1β (clone E7-2-hIL1β) | Santa Cruz Biotechnology | Cat# sc-32294; RRID: AB_627790 |
| Rabbit monoclonal anti-ASC (clone E1E3I) | Cell Signaling Technology | Cat#13833; RRID: AB_2798325 |
| Goat polyclonal anti-monkey IgG, HRP conjugated | Abcam | Cat# ab112767; RRID: AB_10866625 |
| Goat polyclonal anti-monkey IgM, HRP conjugated | Sigma | Cat# SAB3700780; RRID: AB_3101871 |
| Mouse monoclonal anti-CD3 (SP34-2), PerCP-Cy5.5 conjugated | BD Biosciences | Cat#552852; RRID: AB_394493 |
| Mouse monoclonal anti-CD4 (L200), FITC conjugated | BD Biosciences | Cat#550628; RRID: AB_393789 |
| Mouse monoclonal anti-CD8a (RPA-T8), FITC conjugated | BD Biosciences | Cat#561948; RRID: AB_11154582 |
| Mouse monoclonal anti-CD20 (2H7), FITC conjugated | BD Biosciences | Cat#556632; RRID: AB_396501 |
| Mouse monoclonal anti-CD3 (SP34-2), V500 conjugated | BD Biosciences | Cat#560770; RRID: AB_1937322 |
| Mouse monoclonal anti-CD3 (S3.5), Qdot 655 conjugated | Molecular Probes/Life Technologies | Cat#Q10007; RRID: AB_11180600 |
| Mouse monoclonal anti-CD4 (OKT4), Brilliant Violet 650 conjugated | Biolegend | Cat#317436; RRID: AB_2563050 |
| Mouse monoclonal anti-CD8a (RPA-T8), Qdot 650 conjugated | Molecular Probes/Life Technologies | Cat# Q10152; RRID: AB_1500499 |
| Mouse monoclonal anti-CD8a (RPA-T8), Brilliant Violet 570 conjugated | Biolegend | Cat#301038; RRID: AB_2563213 |
| Mouse monoclonal anti-CD20 (2H7), eFluor 450 conjugated | Invitrogen | Cat#48-0209-42; RRID: AB_1633384 |
| Virus strains | ||
| SIVdeltaB670 | Grown in CEM cell line | N/A |
| SIV/17E-Fr | Grown in CEM cell line | N/A |
| SIVmac251 lysate | ZeptoMetrix | Cat#0810011 |
| Biological samples | ||
| SIV-infected macaque plasma | In-house sample archive | See Table S1 for IDs |
| SIV-infected macaque cerebrospinal fluid | In-house sample archive | See Table S1for IDs |
| SIV-infected pigtail macaque basal ganglia (paraffin-embedded tissue blocks) | In-house sample archive | See Table S1 for IDs |
| Uninfected pigtail macaque whole blood | Healthy blood donors | - |
| Critical commercial assays | ||
| MSD U-PLEX Biomarker Group 1 (NHP) Assays, custom 10-cytokine panel | Meso Scale Discovery | Cat#K15068M |
| Bond Polymer Refine Detection Kit | Leica | Cat#DS9800 |
| Bond Polymer Refine Red Detection Kit | Leica | Cat#DS9390 |
| RNAscope 2.5 LS reagent kit RED | ACD | Cat#322150 |
| RNAscope 2.5 LS Probe- SIVmac239 | ACD | Cat#312818 |
| BD OptEIA Reagent Set B | BD Biosciences | Cat#550534 |
| Monkey IgG ELISA kit | Abcam | Cat#ab190549 |
| Nab Protein A/G Spin kit, 0.2 mL | ThermoFisher Scientific | Cat#89950 |
| Bright-Glo Luciferase Assay System | Promega | Cat#E2620 |
| QIAamp MinElute Virus Spin kit | Qiagen | Cat#57704 |
| Experimental models: Cell lines | ||
| Human: T1 (174 x CEM.T1) cells | ATCC | ID#CRL-1991, RRID: CVCL_7904 |
| Human: TZM-bl cells | NIBSC | ID#5011 |
| Experimental models: Organisms/strains | ||
| Pigtail macaques (Macaca nemestrina) | Bred for research | See Table S1 for IDs |
| Rhesus macaques (Macaca mulatta) | Bred for research | See Table S1 for IDs |
| Software and algorithms | ||
| GraphPad Prism (10.1.2) | GraphPad Software | https://www.graphpad.com/ |
| QuPath (0.4.3) | Open source | https://qupath.github.io |
| Concentriq for Research | Proscia | https://proscia.com/concentriq-platform/ |