Table 1. Correlation between the % of reduction in bleeding on marginal probing (BOMP) and changes in the abundance of oral species over time in the therapeutic groups.
| Changes in relative abundance post-therapy (T8) | % of reduction in BOMP |
|---|---|
| Placebo | |
| Actinomyces massiliensis | -0.500* |
| Actinomyces oris | -0.527* |
| Bergeyella HMT-322 | 0.578** |
| Prevotella salivae | -0.488* |
| Capnocytophaga sp. HMT-336 | 0.485* |
| Capnocytophaga sp. HMT-335 | 0.449* |
| Probiotic | |
| Actinomyces HMT-170 | -0.714** |
| Actinomyces HMT-175 | -0.867** |
| Bacteroidetes bacterium HMT-365 | 0.644** |
| Bacteroidetes bacterium HMT-505 | 0.482* |
| Desulfobulbus HMT-041 | 0.505* |
| Escherichia coli | 0.698** |
| Fretibacterium HMT-358 | 0.698** |
| Fusobacterium naviforme | 0.556* |
| Fusobacterium HMT-203 | 0.475* |
| Leptotrichia HMT-223 | -0.584* |
| Leptotrichia wadei | -0.523* |
| Pseudoramibacter alactolyticus | 0.698** |
| Peptostreptococcaceae [XI][G-5][Eubacterium] saphenum | 0.602** |
| Peptostreptococcaceae [XI][G-7][Eubacterium] yurii subsp. schtitka | 0.680** |
| Prevotella baroniae | 0.525* |
| Prevotella dentalis | 0.698** |
| Prevotella enoeca | 0.698** |
| Prevotella HMT-443 | 0.505* |
| Streptococcus cristatus clade-578 | 0.586* |
| Streptococcus oralis subsp.dentisani clade-058 | 0.637** |
| Streptococcus gordonii | 0.470* |
| Saccharibacteria bacterium HMT-955 | 0.477* |
| Treponema HMT-258 | 0.505* |
| Treponema HMT-268 | 0.554* |
| Treponema HMT-517 | 0.698** |
| Veillonellaceae bacterium HMT-135 | 0.505* |
Values represent the Spearman correlation coefficient (rho). Species in green are related to better clinical outcome; i.e. higher reductions in bleeding are correlated with higher abundances of these taxa, whereas increased abundance of species in light orange are associated with more gingival inflammation
(* p < 0.05
** p < 0.01, Mann-Whitney test). T8: 8 weeks after treatments.