Table 1.
Technological characteristics of NPs: average diameter, Polydispersity Index (PDI) and zeta potential (ZP) throughout stability study, (means ± SD, n = 3).
| Formulation | Technological parameters | Time (months) | |||||
|---|---|---|---|---|---|---|---|
| 0 | 2 | 4 | 6 | 8 | 12 | ||
| Cip-SLN | Size (nm) | 300 ± 25 | 305 ± 27 | 309 ± 25 | 312 ± 25 | 324.5 ± 11 | 334.5 ± 31* |
| PDI | 0.295 ± 0.032 | 0.302 ± 0.022 | 0.294 ± 0.031 | 0.315 ± 0.012 | 0.315 ± 0.19 | 0.324 ± 0.12 | |
| ZP (mV) | −18.5 ± 2.5 | −16.1 ± 2.2 | −17.5 ± 1.5 | −15.5 ± 2.1 | -14.9 ± 3.1 | -15.4 ± 3.2 | |
| Amp-Van-SLN | Size (nm) | 290 ± 31 | 295 ± 23 | 289 ± 33 | 302 ± 21 | 314.8 ± 31 | 324.8 ± 24* |
| PDI | 0.350 ± 0.022 | 0.357 ± 0.012 | 0.321 ± 0.012 | 0.341 ± 0.022 | 0.321 ± 0.012 | 0.338 ± 0.014 | |
| ZP (mV) | −17.9 ± 2.3 | −16.4 ± 3.1 | −15.9 ± 2.1 | −16.9 ± 2.1 | -15.25 ± 1.4 | -14.25 ± 1.9 | |
*p value < 0.05.