Figure 4.

Default mode and ECN network connections with compromised pro- and anti-saccade functional connectivity for children with demyelinating disorders compared to typically developing children. Values generated using t-test in network-based statistics, for 26 typically developing children, 17 children with MS and 13 children with MOGAD, with value <3 denoted as non-significant. The connectivity matrices presented in this figure depict group differences in mean node connectivity strength of pairwise associations for each measure, with brighter connectivity colours indicating a larger group difference in mean metric values. There were no significant differences between patient groups in network neural synchrony. PCC, posterior cingulate cortex; mPFC, medial prefrontal cortex; MTL, medial temporal lobe; AG, angular gyrus; DLPFC, dorsolateral prefrontal cortex; ACC, anterior cingulate cortex; PPC, posterior parietal cortex; TDC, typically developing children; MOGAD, children diagnosed with myelin oligodendrocyte glycoprotein-associated disorders; MS, children diagnosed with multiple sclerosis; LH, left hemisphere; RH, right hemisphere.