Table 2.

PLSs path modelling results to examine how neural function may compensate for structural compromise in children with demyelinating disorders and preserve cognition

Path	β	CI95	t-value	P-value
Typically developing children and children with demyelinating disorders
Participant → Structural connectivity	0.50	0.38, 0.64	4.05	0.00018
Participant → Pro-saccade functional connectivity	0.32	−0.31, 0.51	2.87	<0.001
Participant → Anti-saccade functional connectivity	0.38	−0.21, 0.55	1.39	<0.001
Structural connectivity → Pro-saccade functional connectivity	0.24	−0.37, 0.47	3.60	0.001
Structural connectivity → Pro-saccade reaction time	0.27	0.03, 0.49	1.95	0.02
Structural connectivity → Pro-saccade direction errors	0.23	0.13, 0.61	1.29	0.03
Structural connectivity → Anti-saccade functional connectivity	0.31	0.03, 0.66	1.95	<0.001
Structural connectivity → Anti-saccade reaction time	0.49	0.37, 0.66	3.92	0.0003
Structural connectivity → Anti-saccade direction errors	0.22	0.07, 0.45	1.34	0.03
Pro-saccade functional connectivity → Pro-saccade reaction time	−0.25	−0.17, 0.32	−1.79	0.002
Pro-saccade functional connectivity → Pro-saccade direction errors	−0.39	−0.74, 0.32	−2.26	0.03
Anti-saccade functional connectivity → Anti-saccade reaction time	−0.34	−0.23, 0.30	−1.15	<0.001
Anti-saccade functional connectivity → Anti-saccade direction errors	−0.23	−0.47, 0.42	−1.34	0.03
Children diagnosed with multiple sclerosis
Participant → Structural connectivity	0.45	0.36, 0.74	2.39	0.03
Participant → Pro-saccade functional connectivity	−0.32	−0.31, 0.51	2.07	<0.001
Participant → Anti-saccade functional connectivity	−0.50	−0.21, 0.55	2.49	<0.001
Structural connectivity → Pro-saccade functional connectivity	−0.55	−0.37, 0.47	3.51	0.002
Structural connectivity → Pro-saccade reaction time	0.24	0.03, 0.49	1.95	0.02
Structural connectivity → Pro-saccade direction errors	0.46	0.03, 0.73	1.94	0.02
Structural connectivity → Anti-saccade functional connectivity	−0.42	0.37, 0.66	4.17	0.0003
Structural connectivity → Anti-saccade reaction time	0.27	0.03, 0.66	1.95	<0.001
Structural connectivity → Anti-saccade direction errors	0.22	0.37, 0.66	1.18	0.03
Pro-saccade functional connectivity → Pro-saccade reaction time	−0.34	−0.17, 0.32	−3.13	0.004
Pro-saccade functional connectivity → Pro-saccade direction errors	−0.39	−0.79, 0.53	−3.56	0.002
Anti-saccade functional connectivity → Anti-saccade reaction time	−0.56	−0.71, 0.30	−2.07	<0.001
Anti-saccade functional connectivity → Anti-saccade direction errors	−0.49	−0.87, 0.72	−2.53	0.02
Children diagnosed with myelin oligodendrocyte glycoprotein-associated disorders
Participant → Structural connectivity	0.50	−0.44, 0.93	2.91	0.02
Participant → Pro-saccade functional connectivity	−0.42	−0.63, 0.76	1.37	0.04
Participant → Anti-saccade functional connectivity	−0.54	−0.47, 0.24	2.93	0.02
Structural connectivity → Pro-saccade functional connectivity	−0.42	−0.86, 0.32	2.71	0.02
Structural connectivity → Pro-saccade reaction time	0.35	−0.28, 0.58	2.73	0.04
Structural connectivity → Pro-saccade direction errors	0.25	−0.36, 0.67	2.75	0.03
Structural connectivity → Anti-saccade functional connectivity	−0.53	−0.72, 0.65	2.99	0.02
Structural connectivity → Anti-saccade reaction time	0.26	−0.50, 0.95	1.23	0.25
Structural connectivity → Anti-saccade direction errors	0.36	−0.81, 0.98	5.21	0.61
Pro-saccade functional connectivity → Pro-saccade reaction time	−0.37	−0.80, 0.56	−2.53	0.03
Pro-saccade functional connectivity → Pro-saccade direction errors	−0.33	−0.89, 0.42	−2.44	0.04
Anti-saccade functional connectivity → Anti-saccade reaction time	−0.45	−0.71, 0.18	−2.84	0.02
Anti-saccade functional connectivity → Anti-saccade direction errors	−0.31	−0.92, 0.37	−2.99	0.02