Fig. 5. MDP+ whole-cell Cm vaccine reduces incidence and severity of hydrosalpinx.

Representative images of normal (upper panels) or damaged (lower panels) upper genital tracts from adjuvant control (a) or immunized (Ir-Cm + MDP) (b) groups removed 30 days after intravaginal challenge with Cm (n = 20 mice/group). Examples of hydrosalpinx are indicated with black arrows. The percentage of animals with normal oviducts or hydrosalpinx from two combined experiments is presented below each figure. c–e Gross uterine pathology as determined by # of uterine horns displaying hydrosalpinx per mouse (c), highest pathology score for single uterine horns per mouse (d), and cumulative pathology score per mouse (e). Differences between immunized groups were assessed via the Mann–Whitney test. *p ≤ 0.05, ns not significant. Calculated p values for panels c–e are 0.065, 0.031, and 0.034, respectively.