Table 6.

Risk of bias, evaluation of quality related to included studies (QUADAS-2)

Author and year of publication	Risk of bias				Applicability concerns
	Patient selection	Index test	Reference standard	Flow and timing	Patient selection	Index test	Reference standard
Estrela et al., 2008 [50]	V	V	V	?	V	V	V
Estrela et al., 2009 [43]	V	V	V	?	V	V	V
Moura et al., 2009 [44]	V	V	?	X	V	X	V
Weissman et al., 2015 [45]	V	?	V	?	V	X	?
Kanagasingam et al., 2017 [39]	?	V	V	V	?	X	V
Kanagasingam et al., 2017 [40]	?	V	V	V	?	X	V
Nardi et al., 2017 [47]	V	V	V	V	V	V	V
Nardi et al., 2018 [48]	V	V	V	V	V	V	V
Nardi et al., 2020 [49]	V	V	V	?	V	V	V
Jang et al., 2020 [46]	V	V	V	V	V	?	V
Bosoni et al., 2021 [42]	V	V	V	V	V	X	V
Li et al., 2022 [41]	V	V	?	V	V	X	X

V Low Risk; X High Risk; ? Unclear Risk