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. 2024 Nov 8;223(12):e202408173. doi: 10.1083/jcb.202408173

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© 2024 Pankiv et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 2. — BDCPs localize to both secretory and endocytic/recycling compartments. (A) HeLa cells stably expressing 3xFlag-EGFP-NSMAF and mScarlet-RAB5A (left panel) or -RAB14 (right panel) were imaged live. Scale bars 10 µm (main figure) or 1 µm (inset magnifications). (B) HeLa cells stably expressing 3xFlag-EGFP-ALFY and mScarlet-RAB5A (upper panel) or -RAB6A (lower panel) were imaged live. Scale bars 10 µm (left merged) or 1 µm (right merged). (C) Schematics showing localization of ALFY with RAB5 and RAB6. PM- plasma membrane, TGN- trans-Golgi network. (D) HeLa cells stably expressing 3xFlag-EGFP-LRBA and mScarlet-RAB4A, -RAB11A, or -RAB6A were imaged live. Scale bars 10 µm (left merged) or 1 µm (right merged). (E) HeLa cells stably expressing 3xFlag-EGFP-NBEA and mScarlet-LRBA were imaged live. Scale bar 10 µm (left merged) or 1 µm (right merged). (F) Schematics showing localization of LRBA and NBEA with RAB4, RAB11 and RAB6. PM- plasma membrane, EE/SE- early/sorting endosomes, RE- recycling endosomes, TGN- trans-Golgi network.