TABLE 4.
Comparisons in clinical and procedural outcomes according to the occurrence of cervical vasospasm requiring treatment with nimodipine after propensity score overlap weighting.
| Vasospasm treated with nimodipine | Effect size (95% CI) | p value | ||
|---|---|---|---|---|
| No | Yes | |||
| (n = 13,244) | (n = 94) | |||
| Clinical outcome | ||||
| Favorable outcome a | 5772 (43.5) | 48 (51.3) | 1.37 (0.63 to 2.98) | 0.42 |
| Excellent outcome b | 4018 (30.3) | 31 (33.4) | 1.15 (0.72 to 1.85) | 0.55 |
| 90‐day mortality | 3119 (23.6) | 27 (28.7) | 1.30 (0.54 to 3.08) | 0.55 |
| Intracranial hemorrhagic complications | ||||
| Any ICH | 5429 (41.0) | 31 (32.8) | 0.70 (0.44 to 1.11) | 0.13 |
| sICH | 1337 (10.1) | 10 (10.7) | 1.06 (0.42 to 2.68) | 0.90 |
| PH | 1701 (12.8) | 12 (12.7) | 0.98 (0.45 to 2.16) | 0.97 |
| 24 h ASPECTS shift, mean (95% CI) | −0.43 (−1.78 to 0.93) | −0.51 (−1.55 to 0.54) | −0.08 (−1.75 to 1.59) c | 0.92 |
| 24 h NIHSS shift, mean (95% CI) | −3.76 (−5.01 to −2.51) | −3.48 (−4.95 to −2.01) | 0.28 (−0.42 to 0.98) c | 0.41 |
| Procedural outcomes | ||||
| Final mTICI score 2b, 2c or 3 | 11,130 (84.0) | 81 (86.1) | 1.18 (0.48 to 2.92) | 0.72 |
| Final mTICI score 2c–3 | 7627 (57.6) | 60 (63.7) | 1.29 (0.86 to 1.94) | 0.21 |
| Final mTICI score 3 | 5023 (37.9) | 28 (29.5) | 0.68 (0.42 to 1.11) | 0.13 |
| Procedural complication | 649 (4.9) | 3 (3.4) | 0.70 (0.32 to 1.50) | 0.35 |
| Perforations | 213 (1.6) | 0 | NA | NA |
| Emboli in a new territory | 440 (3.3) | 3 (3.4) | 1.01 (0.47 to 2.17) | 0.98 |
| Number of passes | 2 (1 to 3) | 2 (1 to 3) | 1.08 (0.87 to 1.34) | 0.48 |
Note: Values n (%) are estimated in the propensity score overlap weighted cohort unless otherwise indicated.
Abbreviations: ASPECTS, Alberta Stroke Program Early CT Score; CI, confidence intervals; ICH, intracerebral hemorrhage; IQR, interquartile range; mTICI, modified Thrombolysis In Cerebral Infarction; NIHSS, National Institutes of Health Stroke Scale; PH, parenchymal hematoma of type 1 and 2; sICH, symptomatic intracerebral hemorrhage.
Pre‐specified primary outcome defined as a 90‐day mRS score of 0–2, or equal to pre‐stroke mRS score.
Defined as a 90‐day mRS score of 0–1, or equal to pre‐stroke mRS score.
Baseline‐adjusted mean difference; Descriptive parameters and effect sizes (odds ratio or mean difference) were calculated after handling missing values for variables included in the propensity score using multiple imputations.