Table 1.

State of the art of some representative computational studies for simulating CRT. In the bottom part we highlighted those works that included some preliminary investigations about CRT optimization. LV (Left Ventricle), RV (Right Ventricle), RA (Right Atrium), EM (Electro-Mechanics), EP (Electro-Physiology), MEC (Mechanics), Opt CRT (Optimization of Cardiac Resynchronization Therapy)

Work	Human	Fibrosis	EM	EP	MEC	Opt	RV	Epicardial	Closed	RA
	LV			Calibr.	Calibr.	CRT		Veins	LPM	pacing
										preload
Kerckhoffs et al. (2003)	$\times$	$\times$	$✓$	$\times$	$\times$	$\times$	$\times$	$\times$	$\times$	$\times$
Kerckhoffs et al. (2009)	${✓}^{†}$	$\times$	$✓$	$\times$	$\times$	$\times$	$✓$	$\times$	$\times$	$\times$
Sermesant et al. (2012)	$✓$	$✓$	$✓$	${✓}^{+}$	$✓$	$\times$	$✓$	$\times$	$\times$	$\times$
Hyde et al. (2015)	$✓$	$\times$	$\times$	$\times$	$\times$	$\times$	$✓$	$\times$	$\times$	$\times$
Kayvanpour et al. (2015)	$✓$	$\times$	$✓$	$✓_{}^{\ast }$	$\times$	$\times$	$✓$	$\times$	$\times$	$\times$
Crozier et al. (2016)	$✓$	$\times$	$✓$	${✓}^{\ast }$	$✓$	$\times$	$✓$	$\times$	$\times$	$\times$
Costa et al. (2020)	$✓$	$✓$	$\times$	$\times$	$\times$	$\times$	$\times$	$\times$	$\times$	$\times$
Reumann et al. (2007)	$✓$	$\times$	$\times$	$\times$	$\times$	$✓$	$✓$	$\times$	$\times$	$\times$
Villongco et al. (2016)	$✓$	$✓$	$\times$	${✓}^{\ast }$	$\times$	$✓$	$✓$	$\times$	$\times$	$\times$
Pluijmert et al. (2016)	$\times$	$\times$	$✓$	$\times$	$\times$	$✓$	$✓$	$\times$	$✓$	$\times$
Lee et al. (2017)	$✓$	$✓$	$✓$	$✓_{}^{\ast }$	$✓$	$✓$	$\times$	$\times$	$\times$	$\times$
Isotani et al. (2020)	$✓$	$✓$	$✓$	$\times$	$✓$	$✓$	$✓$	$\times$	$✓$	$\times$
Albatat et al. (2021)	$✓$	$✓$	$\times$	$\times$	$\times$	$✓$	$✓$	$\times$	$\times$	$\times$
Fan et al. (2022)	$\times$	$✓$	$✓$	$\times$	$✓$	$✓$	$\times$	$\times$	$✓$	$✓$
Present work	$✓$	$✓$	$✓$	$✓$	$✓$	$✓$	$\times$	$✓$	$\times$	$\times$

$_{}^{†}$ canine LV has been used

$_{}^{+}$ EP calibration performed by means of anatomical electrical mapping

$_{}^{\ast }$ EP calibration performed by means of ECG measures