Table 3.

Non-calibrated parameters used in the numerical simulations: Mechanical Activation parameters taken from Regazzoni et al. (2020), Passive Mechanics parameters taken from Usyk et al. (2002), Pericardium and Windkessel parameters taken from Stella et al. (2022)

	$S{L}_0[\mathrm{\mu }\text{m}]$	${\overline{k}}_d[\mathrm{\mu }M]$	${\alpha }_{k_d}[\mathrm{\mu }M{\mathrm{\mu }}^{-1}\text{m}]$	$\gamma [-]$
Mechanical	2.2	0.4	$-0.2083$	30
activation	$k_{\text{off}}[{\text{s}}^{-1}]$	$k_{\text{basic}}[{\text{s}}^{-1}]$	${\mu }_{f_{\mathcal{P}}}^0[{\text{s}}^{-1}]$	${\mu }_{f_{\mathcal{P}}}^1[{\text{s}}^{-1}]$
	40	8	32.255	0.768
	$b_f$ [-]	$b_s$ [-]	$b_n$ [-]	$b_{\mathit{fs}}$ [-]
Passive	8	6	3	12
mechanics	$b_{\mathit{fn}}$ [-]	$b_{\mathit{sn}}$ [-]	C [kPa]	K [kPa]
	3	3	0.88	50
Pericardium	$K_{\perp }^{\text{epi}}[{\text{Pa}}^{-1}]$	$K_{\Vert }^{\text{epi}}[{\text{Pa}}^{-1}]$	$C_{\perp }^{\text{epi}}[{\text{Pa}}^{-1}]$	$C_{\Vert }^{\text{epi}}[{\text{Pa}}^{-1}]$
	$2·{10}^5$	$2·{10}^4$	$2·{10}^4$	$2·{10}^3$
Windkessel	${\overline{p}}_{\text{MVO}}^{0D}[\text{mmHg}]$	${\overline{p}}_{\text{ED}}^{0D}[\text{mmHg}]$	$C[{\text{m}}^3{\text{Pa}}^{-1}]$
	5	10	$4.5·{10}^{-9}$