Table 1.
Donor Characteristics by Stage of Completion of the Donor Evaluation Process
| N (Column %), Median (25th and 75th Percentile), or Mean ± SD | Total |
Initial Online Screen |
Proceeded to Laboratory Testing or Telephone Interview |
Presented for In-person Donor Evaluation |
P |
|---|---|---|---|---|---|
| 1,347 (100.0%) | 961 (71.3%) | 171 (12.7%) | 215 (16.0%) | ||
| Dropped out of the evaluation | 1,018 (76) | 928 (97) | 90 (53) | 0 (0) | <0.001 |
| Deemed ineligible for donation | 158 (12) | 33 (3) | 81 (47) | 44 (20) | <0.001 |
| Age (y) | 0.044 | ||||
| <40 | 613 (46) | 437 (45) | 70 (41) | 106 (49) | |
| 40-64 | 607 (45) | 430 (45) | 78 (46) | 99 (46) | |
| 65+ | 127 (9) | 94 (10) | 23 (13) | 10 (5) | |
| Female | 951 (71) | 672 (70) | 130 (76) | 149 (69) | 0.25 |
| Race | 0.17 | ||||
| Asian/Pacific Islander | 211 (16) | 142 (15) | 25 (15) | 44 (20) | |
| Hispanic | 294 (22) | 200 (21) | 46 (27) | 48 (22) | |
| Non-Hispanic Black | 98 (7) | 73 (8) | 9 (5) | 16 (7) | |
| Non-Hispanic White | 744 (55) | 546 (57) | 91 (53) | 107 (50) | |
| Donor relationship to intended recipient | <0.001 | ||||
| Parent | 61 (5) | 37 (4) | 12 (7) | 12 (6) | |
| Child | 110 (8) | 72 (7) | 10 (6) | 28 (13) | |
| Sibling | 135 (10) | 91 (9) | 17 (10) | 27 (13) | |
| Spouse | 104 (8) | 68 (7) | 5 (3) | 31 (14) | |
| Extended family | 192 (14) | 147 (15) | 13 (8) | 32 (15) | |
| Friend/Coworker | 404 (30) | 304 (32) | 50 (29) | 50 (23) | |
| Altruistic | 67 (5) | 34 (4) | 15 (9) | 18 (8) | |
| Other/Unknown | 274 (20) | 208 (22) | 49 (29) | 17 (8) | |
| 15-year predicted ESKD riska (%) | N/A | N/A | 0.08 (0.04-0.13)b | 0.08 (0.05-0.15) | 0.74 |
| How do you rate your overall health? | 3.8 ± 0.8 | 3.8 ± 0.8 | 3.4 ± 0.9 | 4.1 ± 0.8 | <0.001 |
| How well do you carry out your social activities & roles? | 4.0 ± 0.9 | 4.0 ± 0.9 | 3.8 ± 1.0 | 4.1 ± 0.7 | 0.019 |
| PROMIS physical and mental health | |||||
| Global physical health | 16.3 ± 2.3 | 16.3 ± 2.2 | 15.3 ± 2.7 | 17.0 ± 1.9 | <0.001 |
| To what extent are you able to carry out your everyday physical activities? | 4.7 ± 0.6 | 4.7 ± 0.6 | 4.5 ± 0.8 | 4.8 ± 0.5 | <0.001 |
| How would you rate your physical health? | 3.6 ± 0.9 | 3.7 ± 0.9 | 3.1 ± 1.0 | 3.9 ± 0.8 | <0.001 |
| How would you rate your fatigue on average? | 3.9 ± 0.8 | 3.9 ± 0.8 | 3.7 ± 0.9 | 4.1 ± 0.7 | <0.001 |
| How would you rate your pain, with 0 being none and 10 being the worst pain imaginable? | 2.0 ± 2.1 | 2.1 ± 2.1 | 2.3 ± 2.3 | 1.5 ± 1.9 | <0.001 |
| Global mental health | 14.9 ± 3.0 | 14.9 ± 3.1 | 14.3 ± 3.1 | 15.5 ± 2.7 | <0.001 |
| In general, how would you rate your quality of life? | 4.0 ± 0.9 | 4.0 ± 0.8 | 3.7 ± 0.9 | 4.2 ± 0.8 | <0.001 |
| In general, how would you rate your mental health, including your mood and ability to think? | 3.7 ± 1.0 | 3.7 ± 1.0 | 3.6 ± 1.0 | 3.9 ± 0.9 | 0.005 |
| How often are you bothered by emotional problems such as feeling anxious, depressed, or irritable? | 3.4 ± 0.9 | 3.4 ± 0.9 | 3.4 ± 0.9 | 3.4 ± 0.8 | 0.84 |
| In general, how would you rate your satisfaction with your social activities and relationships? | 3.8 ± 1.0 | 3.8 ± 1.0 | 3.7 ± 1.0 | 4.0 ± 0.9 | 0.002 |
| Davies and Ware Health Perceptions | |||||
| Summary score: health outlook | 15.3 ± 2.5 | 15.3 ± 2.5 | 14.6 ± 2.6 | 15.8 ± 2.1 | <0.001 |
| You probably will get sick a lot in the future. | 4.3 ± 0.8 | 4.3 ± 0.8 | 4.1 ± 1.0 | 4.5 ± 0.7 | <0.001 |
| You expect to have better health than others. | 3.6 ± 0.9 | 3.6 ± 0.9 | 3.4 ± 0.9 | 3.7 ± 0.9 | 0.005 |
| Your health will be worse in the future compared to now. | 3.4 ± 1.1 | 3.4 ± 1.1 | 3.3 ± 1.1 | 3.4 ± 1.1 | 0.31 |
| You expect a healthy life. | 4.1 ± 0.8 | 4.1 ± 0.8 | 3.9 ± 0.8 | 4.2 ± 0.7 | <0.001 |
| Summary score: resistance to illness | 15.4 ± 2.7 | 15.4 ± 2.7 | 15.2 ± 2.7 | 15.7 ± 2.4 | 0.21 |
| You get sick easier than others. | 4.4 ± 0.9 | 4.3 ± 0.9 | 4.2 ± 0.9 | 4.5 ± 0.8 | 0.011 |
| People get sick easier than you do. | 3.7 ± 0.9 | 3.6 ± 0.9 | 3.7 ± 0.9 | 3.7 ± 0.9 | 0.70 |
| Your body resists illness. | 3.4 ± 0.9 | 3.4 ± 1.0 | 3.5 ± 0.9 | 3.4 ± 0.9 | 0.99 |
| Whenever something is going around, you catch it. | 3.9 ± 0.8 | 3.9 ± 0.8 | 3.8 ± 0.9 | 4.0 ± 0.7 | 0.054 |
| Summary score: health worry∗ | 13.1 ± 2.4 | 13.2 ± 2.4 | 12.8 ± 2.4 | 13.2 ± 2.3 | 0.19 |
| You never worry about your health.∗ | 3.3 ± 1.1 | 3.3 ± 1.1 | 3.5 ± 1.0 | 3.1 ± 1.1 | <0.001 |
| You worry about your health more than others.∗ | 2.5 ± 1.1 | 2.5 ± 1.1 | 2.6 ± 1.0 | 2.3 ± 1.0 | 0.089 |
| Others are more concerned about their health than you are yours.∗ | 3.6 ± 1.0 | 3.6 ± 1.0 | 3.4 ± 1.0 | 3.9 ± 0.9 | <0.001 |
| Your health is a concern (a priority).∗ | 3.7 ± 1.0 | 3.8 ± 1.0 | 3.3 ± 1.0 | 3.8 ± 1.0 | <0.001 |
| Summary score: sickness orientation | 7.4 ± 1.5 | 7.4 ± 1.5 | 7.4 ± 1.5 | 7.5 ± 1.5 | 0.69 |
| Getting sick is part of life. | 3.5 ± 1.0 | 3.5 ± 1.0 | 3.6 ± 1.0 | 3.6 ± 1.0 | 0.35 |
| You accept that sometimes you are sick. | 3.9 ± 0.8 | 3.9 ± 0.7 | 3.8 ± 0.7 | 3.9 ± 0.8 | 0.95 |
Note: Higher scores represent more positive health status or positive health perception with the exception of the health worry summary score and its components, denoted by an asterisk (∗), where greater values indicate greater concern for one’s health.
ESKD, end-stage kidney disease.
The PROMIS global physical and mental health scores range from a minimum of 4 and maximum of 20, with greater scores indicating better health. The individual questions on the PROMIS survey have responses on a Likert scale of 1 to 5, with the exception of the pain score which ranges from 0-10 (but is rescaled to a scale of 1-5 during computation of the summative PROMIS scores).
For the Davies and Ware Health Perceptions, individual question responses were scored on a Likert scale between 1 and 5, with higher scores represent more positive health status or positive health perception with the exception of the health worry summary score and its components, where greater values indicate greater concern for one’s health. Davies and Ware Summary Scores were a simple summation of their constituent scores, with a maximum score of 20 for health outlook, resistance to illness, and health worry summary scores, and maximum of 10 for the sickness orientation summary score.
This is the predicted % risk of the donor developing kidney failure over a 15-year horizon if they undergo donation.
N = 62 who completed laboratory testing and had sufficient data elements for a 15-year ESRD risk to be computed.