Table 2.

Impact of biomarkers included in previous prognostic models.

	Univariate analysis				Multivariate analysis
Variable	N	HR	95% CI	p Value	N	HR	95% CI	p Value
IgM ≥10 g/L	912	4.41	2.96–6.57	<0.001	495	2.16	1.23–3.78	0.007
BM lymphocytes ≥20%	601	3.79	2.50–5.73	<0.001	495	3.47	2.04–5.93	<0.001
β2‐microglobulin ≥3 mg/L	727	2.38	1.64–3.46	<0.001	495	1.90	1.17–3.09	0.010
Albumin <4 g/dL	864	2.59	1.82–3.69	<0.001	495	1.58	0.97–2.56	0.060
IgA <0.6 g/L	899	3.14	2.14–4.63	<0.001	495	‐	‐	‐
IgG <6 g/L	901	1.51	1.05–2.17	0.025	495	‐	‐	‐
Hemoglobin <11.5 g/dL	920	2.56	1.69–3.87	<0.001	495	‐	‐	‐
LDH ≥450 UI/L	857	1.37	0.51–3.72	0.533	495	‐	‐	‐

Abbreviations: BM, bone marrow; CI, confidence interval; HR, hazard ratio; LDH, lactate dehydrogenase; N, number of patients for each biomarker.