Figure 2. Heatmap of the correlation coefficients between plasma 5-FU concentration and clinicopathologic factors.

The heat map is created so that a correlation coefficient of 1 is red and -1 is blue. The numbers in the figure represent correlation coefficients.

The heatmap of correlation coefficients among the clinicopathologic factors also demonstrated that the plasma 5-FU concentration gradient correlated with diarrhea and nausea. Adverse events correlated with plasma 5-FU concentration were plasma 5-FU concentration after one hour and diarrhea, and concentration gradient and diarrhea/nausea.

①:plasma 5-FU Concentration after one hour; ②: plasma 5-FU Concentration after two hours; ③: ①ｰ②Concentration gradient; ④: Plasma 5-FU concentration at the highest of 1 or 2 hours;　⑤: Sex; ⑥: Age; ⑦: Body mass index; ⑧: Body surface area; ⑨: Creatinine clearance; ⑩: clinical Stage; ⑪: Purpose of Chemotherapy; ⑫: Primary resection; ⑬: Chemotherapy target lesion; ⑭: Capecitabine dosage; ⑮: Rejimen; ⑯: Diarrhea; ⑰: Stomatitis; ⑱: Nausea; ⑲: Anorexia; ⑳: Fatigue; ㉑: Hand-foot syndrome; ㉒:Constipation; ㉓:Leukopenia; ㉔: Neutropenia; ㉕:Anemia; ㉖:Thrombocytopenia