Table 3. Relationship between plasma 5-FU concentration and adverse events.
Concentrations are expressed as median (interquartile range). The differences between groups were estimated using the Mann-Whitney test for continuous variables.
| Adverse events | 5-FU blood concentration (ng/ml) | p-value | |
| Diarrhea | (－) | 94 [64.5–149.5] | |
| (＋) | 129 [69–192] | 0.363 | |
| Stomatitis | (－) | 95.5 [32–307] | |
| (＋) | 137 [38–187.5] | 0.361 | |
| Nausea | (－) | 91.0 [67–149.7] | |
| (＋) | 131 [60.5–187] | 0.604 | |
| Loss of appetite | (－) | 123.5 [60.7–159.5] | |
| (＋) | 95.5 [68.5–187.5] | 0.884 | |
| Fatigue | (－) | 132.5[60.7–193.5] | |
| (＋) | 95.5 [60.7–136] | 0.384 | |
| Hand–foot syndrome | (－) | 119.0 [68.7–139.7] | |
| (＋) | 142.5[64.5–229.5] | 0.299 | |
| Constipation | (－) | 110.5 [67.4–169.5] | |
| (＋) | 104 [64.5–172.5] | 0.99 | |
| Leukopenia | (－) | 111.5 [66.5–148.2] | |
| (＋) | 106 [67–20.5.] | 0.446 | |
| Neutropenia | (－) | 95.5 [65.7–143] | |
| (＋) | 131.5 [73–205.5] | 0.194 | |
| Anemia | (－) | 127.0 [69–186] | |
| (＋) | 94 [41.5–148.5] | 0.157 | |
| Thrombocytopenia | (－) | 95.5 [63.3–151.7] | |
| (＋) | 126.5 [70.5–190.5] | 0.392 | |