Table 6. The study’s inclusion and exclusion criteria.

The study’s inclusion and exclusion criteria are shown as supplemental Table 6.

Inclusion criteria	Age: ≥20 years
	Histologically diagnosed colorectal cancer.
	Life expectancy: ≥3 months
	Eastern Cooperative Oncology Group performance status: 0-1
	Neutrophil count: ≥1000/mm3
	Hemoglobin: ≥8.0 g /dL
	Platelet count: ≥75,000/mm3
	Serum creatinine: ≤1.5 times the upper limit of normal
	Total bilirubin: ≤2.0 mg /dL
	Aspartate transaminase: ≤100 IU/L (≤200IU/L for patients with metastatic liver tumor)
	Alanine transaminase: ≤100 International Unit (IU) / litre (L) (≤200IU/L for patients with metastatic liver tumor)
Exclusion criteria	Serious drug allergy
	Severe peripheral neuropathy
	Active infection
	Uncontrollable hypertension
	Mechanical or paralytic bowel obstruction
	Uncontrolled diabetes mellitus
	Cirrhosis
	Unstable ischemic heart disease
	Multiple malignancy within the last five years
	Ascites
	Pleural effusion
	Pericardial effusion
	Uncontrolled diarrhea