Table 3.
Odds ratio and P values for rs2346609 and rs35042965 by study and by sex
| Female | Male | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | L95 | U95 | P value | OR | L95 | U95 | P value | P value sex difference | |
| rs2346609 (chr16:7260432a) RBFOX1 | |||||||||
| GliomaScan | 1.20 | 1.00 | 1.43 | 0.0536 | 0.99 | 0.84 | 1.16 | 0.8613 | 0.1195 |
| AGOG | 1.17 | 0.94 | 1.46 | 0.1677 | 0.95 | 0.78 | 1.16 | 0.6419 | 0.1800 |
| GICC | 1.24 | 1.10 | 1.41 | 0.0008 | 0.99 | 0.88 | 1.10 | 0.7969 | 0.0066 |
| Mayo/UCSF | 1.31 | 1.11 | 1.56 | 0.0019 | 0.99 | 0.86 | 1.14 | 0.9173 | 0.0131 |
| Meta-analysis | 1.24 | 3.21E−07* | 0.98 | 0.6474 | |||||
| rs35042965 (chr1:14184325a) PRDM2 | |||||||||
| GliomaScan | 0.99 | 0.79 | 1.23 | 0.9103 | 0.91 | 0.74 | 1.10 | 0.3269 | 0.5709 |
| AGOG | 1.01 | 0.77 | 1.33 | 0.9322 | 0.75 | 0.58 | 0.97 | 0.0285 | 0.1180 |
| GICC | 0.98 | 0.83 | 1.14 | 0.7734 | 0.81 | 0.71 | 0.92 | 0.0016 | 0.0702 |
| Mayo/UCSF | 0.99 | 0.80 | 1.22 | 0.9203 | 0.77 | 0.65 | 0.92 | 0.0030 | 0.0744 |
| Meta-analysis | 0.99 | 0.7968 | 0.81 | 1.54E−06* | |||||
*, P value < multiple-testing adjusted threshold in SNP meta-analysis (P < 3.3E−06 = 0.05/15,148 SNPs).
a
Base pair location is hg19 build.