Table 2.
Baseline | 6 Mo | 12 Mo | |||
---|---|---|---|---|---|
Mean ± SD | Pc | ||||
BMI ≤30 | |||||
SBP, mm Hg | Overall (N = 122) | 125.2 ± 14.6 | 123.1 ± 12.4 | 124.42 ± 13.4 | NS |
High dose (N = 54) | 126.8 ± 14.3 | 122.5 ± 13.4 | 125.5 ± 12.9 | NS | |
Low dose (N = 68) | 124 ± 14.7 | 123.6 ± 11.7 | 123.3 ± 13.7 | NS | |
DBP, mm Hg | Overall (N = 122) | 72.6 ± 9.8 | 70.4 ± 9.2 | 70.6 ± 9.2 | NS |
High dose (N = 54) | 73.1 ± 10.4 | 69.8 ± 9.3 | 71.1 ± 7.9 | NS | |
Low dose (N = 68) | 72.2 ± 9.3 | 70.9 ± 9.2 | 70.3 ± 10.1 | NS | |
BMI >30 | |||||
SBP, mm Hg | Overall (N = 99) | 132.5 ± 17.4a | 128.3 ± 14.3b | 125.2 ± 14b | <.0001 |
High dose (N = 56) | 132.9 ± 17.6a | 129.3 ± 12.6a | 125.8 ± 11.5b,d | .006 | |
Low dose (N = 43) | 132 ± 17.2a | 127.1 ± 16.4a | 124.5 ± 16.9b,d | .024 | |
DBP, mm Hg | Overall (N = 99) | 77.3 ± 10.9a | 73.9 ± 9.4a | 73.8 ± 9.1b,e | .010 |
High dose (N = 56) | 77.3 ± 10.6a | 74.3 ± 9.1a | 73.3 ± 7.9a | .020 | |
Low dose (N = 43) | 77.3 ± 11.4 | 73.5 ± 9.9 | 74.5 ± 10.5 | NS |
Abbreviations: ANOVA, analysis of variance; BMI, body mass index; DBP, diastolic blood pressure; SBP, systolic blood pressure; NS, not significant.
a, b post hoc t test from ANOVA: Values with different letters are statistically significantly different from each other.
c P value from within treatment comparisons, by repeated-measures ANOVA.
d P value at 6 and 12 months equals .055.
e P value at baseline and 12 months is less than .05.