Figure 6. Proposed model of FLNA as a regulator of MLC phosphorylation.

Schematic diagram illustrating a proposed model in which FLNA regulates MLC phosphorylation and cell contraction in platelets. (A) FLNA acts as a major scaffolding protein for both RhoA and ROCK to facilitate the phosphorylation (and therefore inhibition) of MLC phosphatase after thrombin activation. (B) FLNA modulates the activity of PKC which also contributes to MLC phosphorylation.