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. 2024 Nov 12;26:199. doi: 10.1186/s13075-024-03417-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Frequency of changes in systemic helper T (Th) cells in SMILE Tg mice. (A) Representative immunofluorescence images show the spleen tissues of C57BL/6 and SMILE Tg stained with anti-CD4 antibody (green) and anti-IL-17 antibody (red). Nuclei were stained by DAPI (blue). (B) The splenocytes of C57BL/6 and SMILE Tg were analyzed by flow cytometry. Th1 (CD4⁺ IFNγ⁺), Th2 (CD4⁺ IL-4⁺), Th17 (CD4⁺ IL-17⁺) and regulatory T cell (Treg; CD4⁺ CD25^high Foxp3⁺) populations are shown. The data are presented as the mean ± standard deviation. *p < 0.05 and ***p < 0.001