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. 2024 Nov 12;26:199. doi: 10.1186/s13075-024-03417-3

Fig. 5.

Fig. 5

Schematic diagram of therapeutic effect of SMILE on OA through the regulation of AMPK and cytokine production. SMILE overexpression leads to an increase in AMPK and a decrease in STAT3 in joint tissue, in addition to changing the proportion of immune cell subsets. SMILE overexpression also suppresses both the expression of OA-catabolic factors and inflammatory cytokine production