Table 2.
Comparison of commonly used laboratory parameters between the described groups
| Parameters | MS and AID | MS without AID | MS and ABF | MS without AID and ABF |
|---|---|---|---|---|
| Cells > 4, % (n) | 55.8 (24/43) | 67.6 (184/272) | 65.6 (42/64) | 68.3 (142/208) |
| Cells per µl, median (IQR 25%—IQR 75%) | 5.2 (2.8–11) | 7 (3–13.9) | 6.2 (3–13) | 7 (3–14) |
| CSF lactate (mmol/l), median (IQR 25%—IQR 75%) | 1.6 (1.5–2) | 1.8 (1.6–2.2) | 1.7 (1.5–2.1) | 1.8 (1.6–2.2) |
| OCB positivity, % (n) | 100 (43/43) | 98.2 (267/272) | 98.4 (63/64) | 98.6 (205/208) |
| Presence of intrathecal IgG synthesis, % (n) | 67.4 (29/43) | 61.4 (167/272) | 64.1 (41/64) | 60.1 (125/208) |
| Presence of intrathecal IgA synthesis, % (n) | 11.6 (5/43) | 10.3 (28/272) | 10.9 (7/64) | 10.1 (21/208) |
| Presence of intrathecal IgM synthesis, % (n) | 37.2 (16/43) | 29.4 (80/272) | 29.7 (19/64) | 29.3 (61/208) |
IQR, interquartile range; OCB, oligoclonal bands; IgG, immunoglobulin G; IgA, immunoglobulin A; IgM, immunoglobulin M; MS and AID, multiple sclerosis patients with comorbid autoimmune disease; MS without AID, multiple sclerosis patients without comorbid autoimmune disease; MS and ABF, multiple sclerosis patients with isolated antibody finding; MS without ABF and without AID, multiple sclerosis patients without isolated antibody finding or comorbid autoimmune disease