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. 2024 Nov 12;24:412. doi: 10.1186/s12871-024-02795-0

Table 4.

Characteristics of ciprofol and propofol

Ciprofol Propofol
Chemical Formula

C14H20O

(R)-2-(1-cyclopropylethyl)-6-isopropylphenol

C12H18O

2,6-diisopropylphenol

pKa Value 11.8 11.1
Potency Difference 5 more potent than propofol -
Solution Type Lipid-in-water solution Lipid-based solution
Complications Hypotension, bradycardia, apnea, respiratory depression, hypoxia Propofol infusion syndrome
Dosage (Adults) 0.4 mg/kg Typically 1.5–2.5 mg/kg for induction, followed by maintenance infusion rates
Dosage (Children) - Typically 1–3 mg/kg for induction, followed by maintenance infusion rates
Cost Difference 1–2 times higher than propofol Varies depending on the region and brand