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. 2024 Nov 11;16:130. doi: 10.1186/s13073-024-01399-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 2 — The host association and genetic characteristics of the PCs. a A graph of the plasmid-exchange network in Enterobacteriaceae. Nodes show the plasmids (gray pots) and genera of the hosts (colored) and the colored edges show the presence of the plasmids in the corresponding hosts. b Histogram of the eigenvector centralities of genera in the network in part a. c Scatter plot of the average carriage of carbapenemase genes (X-axis) and the iuc gene (Y-axis) in each PC. Each circle represents a PC and is sized proportional to the number of associated plasmids and color-coded as in the Key. The two dashed lines show the criteria for assigning PCs as CR-PCs (≥ 0.2 carbapenemases), hvPCs (≥ 0.2 iuc), or hvCR-PCs. d Bubble plot of the HC1360 distribution for each PC. Each bubble indicates a PC and is sized relative to the associated plasmids. The piechart in each bubble shows the proportional presence of the PC in different HC1360s. The halos surrounding some bubbles indicate that these PCs belong to one of the CR-PCs (red), hvPCs (blue), or hvCR-PCs (purple), as defined in part c