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. 2024 Nov 11;30:209. doi: 10.1186/s10020-024-00934-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Clinicopathological characteristics of NSCLC patients and PDX tumor growth characteristics. A Clinicopathological characteristics of NSCLC patients. ADC, adenocarcinoma; SCC, squamous cell carcinoma; LCNEC, Large cell neuroendocrine carcinoma; LUL, left upper lobe; RLL, right lower lobe; RML, right middle lobe; LLL, left lower lobe; RUL, right upper lobe. B Kaplan–Meier curves for DFS and OS of NSCLC patients according to the engraftment status of their corresponding PDXs. Kaplan–Meier survival analysis and log-rank test were used to perform the survival analysis (No-PDX: n = 49; PDX: n = 13). C The scatter plot represents the time to reach 300 mm³ tumor volume in mice; each point represents the time taken for a tumor to reach 300mm³. D Growth curves of PDX engrafted tumors from 9 ADC patients. E Growth curves of PDX engrafted tumors from 4 SCC patients. F Growth curves of 3 PDX engrafted tumors from one LCNEC patient