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. Author manuscript; available in PMC: 2024 Nov 12.
Published in final edited form as: J Med Chem. 2023 Jan 26;66(3):1928–1940. doi: 10.1021/acs.jmedchem.2c01731

Fig. 4. Unoccupied pocket off the indole.

Fig. 4.

A. The crystal structure of TW-8-67-2 bound to CDK2 reveals an unoccupied hydrophobic pocket off the R6 position of the indole (PDB 7RWF). B. The chlorine atom of compound 34 is nested in this subsite (PDB 7S4T). C. Overlay of crystal structures of CDK2 bound to TW-8-67-2 (pink; CDK2 in cyan; PDB ID 7RWF) and compound 34 (yellow; CDK2 in green; PDB ID 7S4T).